EarlyCDT-Lung: a simple blood test for the early detection of lung cancer
1 Zhong L, et al. Profiling tumour-associated antibodies for early detection of non-small cell lung cancer. J Thor Oncol 2006; 1:513-519.
2 Jett J, et al. Determination of the detection lead time for autoantibody biomarkers in early stage lung cancer using the UKCTOCS cohort. J Thor Oncol 2017; 12(11):S2170.
3 For patients with one or more nodules the combined test results ‘Moderate Level’ and ‘High Level’ have Accuracy 83% and PPV 59% (1 in 1.7). For a ‘High Level’ test result: Accuracy 84% and PPV 1 in 1.3 (78%). (Based on lung cancer prevalence of 20%)
4 In asymptomatic patients at increased risk5: Accuracy 92%, PPV 10% (1 in 10); for combined Moderate and High Level results. For a High Level test result Accuracy 97% and PPV 1 in 5 (20%). (Based on lung cancer prevalence of 1.2% increased by a conservative 50% to account for the “look forward” ability for autoantibodies to be detected prior to a cancer being detectable by imaging1)
5 Combined Moderate and High Level test result: Specificity 93%; Sensitivity 41%. High Level test result: Specificity 98% and Sensitivity 28%
6 Increased risk is defined as 20+ pack years and 50+ years, or 40+ years and another risk factor
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